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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Statistical Software for Data Analysis and Clinical Trials01:12

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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
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Random Error01:04

Random Error

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Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
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Random Variables01:09

Random Variables

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A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
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Osteogenic cells transfer improving root coverage: A randomized clinical trial.

Bruna F R Ferraz1, Vitor T Stuani2, Euloir Passanezi2

  • 1Discipline of Periodontics, Dentistry Course, University of Marilia, UNIMAR, Marilia, Brazil.

Journal of Periodontal Research
|March 14, 2019
PubMed
Summary
This summary is machine-generated.

Osteogenic cell transfer using newly forming bone graft (NFBG) effectively treats deep gingival recessions (≥4 mm), improving clinical attachment levels and periodontal tissue restoration. This method offers an alternative to traditional grafts for significant recession coverage.

Keywords:
newly forming bone techniqueperiodontal plastic surgeryrecessionroot coveragesubepithelial connective tissue graft

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Area of Science:

  • Periodontology
  • Regenerative Dentistry
  • Oral Surgery

Background:

  • Gingival recessions are common, leading to root exposure and potential periodontal issues.
  • Treatments aim to cover denuded roots and restore lost periodontal tissues.
  • Osteogenic cell transfer represents a novel approach to periodontal regeneration.

Purpose of the Study:

  • To evaluate the efficacy of osteogenic cell transfer via newly forming bone graft (NFBG) for treating gingival recessions.
  • To compare NFBG with subepithelial connective tissue graft (SCTG) in a randomized clinical trial.
  • To assess clinical outcomes including root coverage, pocket depth, and attachment level gain.

Main Methods:

  • An interventional, parallel-assignment, single-blinded, randomized study.
  • Miller class I or II gingival recessions >4 mm treated with NFBG + coronally advanced flap (CAF) or SCTG + CAF (control).
  • Clinical parameters assessed at baseline and 3, 6, 9 months post-surgery.

Main Results:

  • Both techniques provided comparable root coverage percentages.
  • NFBG demonstrated superior outcomes in reducing pocket depth and improving clinical attachment level.
  • NFBG also led to greater reductions in plaque accumulation and bleeding on probing.

Conclusions:

  • Osteogenic cell transfer using NFBG is effective for treating deep gingival recessions (≥4 mm).
  • NFBG improves clinical attachment level and root coverage, promoting periodontal tissue restoration.
  • NFBG serves as a viable alternative treatment for significant gingival recessions.