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Published on: February 11, 2016
Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens
Luke P Robertson1,2, Leonardo Lucantoni2, Sandra Duffy2
1Environmental Futures Research Institute , Griffith University , Gold Coast Campus , Southport 4222 , Australia.
Abstract:
A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3- c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC50 values ranging from 1.7 to 4.7 μM.
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