Synthesis of Chiral Bispirotetrahydrofuran Oxindoles by Cooperative Bimetallic-Catalyzed Asymmetric Cascade Reaction
Related Experiment Video
Updated: Jan 27, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Meng-Meng Liu1, Xiao-Chao Yang1, Yuan-Zhao Hua1
1College of Chemistry and Molecular Engineering , Zhengzhou University , 100 Science Avenue , Zhengzhou , Henan 450001 , People's Republic of China.
Abstract:
A new, efficient route for the enantioselective construction of bispirotetrahydrofuran oxindoles is described via the cooperative dinuclear zinc-AzePhenol catalyst. Under mild conditions, a broad range of bispirotetrahydrofuran oxindoles have been synthesized with excellent stereoselectivities through the cascade Michael/hemiketalization/Friedel-Crafts reaction of β,γ-unsaturated α-ketoamide and 2-hydroxy-1-indanone. The reaction can be performed on a gram scale with low catalyst loading (2 mol %) without impacting its efficiency.
More Related Videos
Related Concept Videos
Synthesis and Decomposition Reactions
Cooperative Allosteric Transitions
Cooperative Allosteric Transitions
Base-Catalyzed Aldol Addition Reaction
Acid-Catalyzed Aldol Addition Reaction
Cooperative Binding of Transcription Regulators

