Related Experiment Video
Updated: Jan 27, 2026
The Ladder Rung Walking Task: A Scoring System and its Practical Application.
Published on: June 12, 2009
Moving Beyond Gleason Scoring
Brian Miles, Michael Ittmann, Thomas Wheeler
1From the Department of Urology, The Methodist Hospital, Houston, Texas (Dr Miles); the Departments of Pathology & Immunology (Drs Ittmann and Wheeler and Mr Sayeeduddin) and Molecular and Cell Biology (Dr Rowley), Baylor College of Medicine, Houston, Texas; Instituto de Patologia e Investigacion, Asuncion, Paraguay (Dr Cubilla); Biostatistics/Epidemiology/Research Design (BERD) Core, Departments of Internal Medicine (Dr Lee) and Pathology and Laboratory Medicine (Drs Bu, Ding, Gao, and Ayala), University of Texas Health Sciences Center Medical School, Houston.
Context.—:
The combination of grading and staging is the basis of current standard of care for prediction for most cancers. D. F. Gleason created the current prostate cancer (PCa) grading system. This system has been modified several times. Molecular data have been added. Currently, all grading systems are cancer-cell based.
Objective.—:
To review the literature available on host response measures as reactive stroma grading and stromogenic carcinoma, and their predictive ability for PCa biochemical recurrence and PCa-specific death.
Data Sources.—:
Our own experience has shown that reactive stroma grading and the subsequently binarized system (stromogenic carcinoma) can independently predict biochemical recurrence and/or PCa-specific death, particularly in patients with a Gleason score of 6 or 7. Stromogenic carcinoma has been validated by 4 other independent groups in at least 3 continents.
Conclusions.—:
Broders grading and Dukes staging have been combined to form the most powerful prognostic tools in standard of care. The time has come for us to incorporate measures of host response (stromogenic carcinoma) into the arsenal of elements we use to predict cancer survival, without abandoning what we know works. These data also suggest that our current definition of PCa might need some revision.
Related Concept Videos
01:06Introduction to z Scores
z scores...
01:05Introduction to z Scores
z scores...
01:17z Scores and Area Under the Curve
01:07z Scores and Unusual Values
This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...
01:23Magnetic Field due to Moving Charges
Consider a point charge moving with a constant velocity. Like the electric field, the magnetic field at any point is directly proportional to the magnitude of the charge and inversely proportional to the square of the distance between the source point and the field point. However, unlike the electric field, the magnetic field is always perpendicular to the plane containing the line...
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT