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Low LINC00599 expression is a poor prognostic factor in glioma
Qiang Fu1, Shaoshan Li1, Qingjiu Zhou2
1Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, No.1 Liyushan Road, Urumqi 830054, Xinjiang, China.
Bioscience Reports
|March 15, 2019
Summary
Long non-coding RNA LINC00599 is downregulated in glioma, correlating with poor survival. Upregulating LINC00599 inhibits glioma cell migration and invasion, suggesting its tumor-suppressive role.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) play roles in carcinogenesis.
- The function of LINC00599 in glioma remains unclear.
Purpose of the Study:
- Investigate the clinical and prognostic significance of LINC00599 in glioma.
- Determine the effect of LINC00599 on glioma cell migration and invasion.
Main Methods:
- Analyzed LINC00599 expression in The Cancer Genome Atlas (TCGA) database across 31 cancer types.
- Confirmed expression levels in glioma tissues and cell lines.
- Performed in vitro studies on glioma cell migration and invasion.
Main Results:
- LINC00599 expression was reduced in lower-grade glioma (LGG) and glioblastoma multiforme (GBM) tissues.
- Lower LINC00599 levels correlated with higher WHO grades and poorer patient survival.
- Upregulation of LINC00599 inhibited glioma cell migration and invasion via epithelial-mesenchymal transition (EMT).
Conclusions:
- LINC00599 functions as a tumor suppressor in glioma.
- Decreased LINC00599 expression is linked to glioma progression and poor prognosis.
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