Related Experiment Video

Updated: Jan 27, 2026

Methanol Independent Expression by Pichia Pastoris Employing De-repression Technologies
05:30

Methanol Independent Expression by Pichia Pastoris Employing De-repression Technologies

Published on: January 23, 2019

14.4K

Correction: FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer

C T Karadedou1, A R Gomes1, J Chen1,2

  • 1Department of Surgery and Cancer, Cancer Research-UK Labs, Imperial College London, Hammersmith Hospital Campus, London, UK.

Oncogene
|March 15, 2019
PubMed

Insights

This study corrects image duplication errors for fibroblast growth factor 7 (FGF7) in MDA-MB-231 and SKBR-3 cells. The corrected images accurately represent FGF7 localization and levels in these cancer cell lines.

Area of Science:

  • Cell biology
  • Molecular biology
  • Cancer research

Context:

  • Fibroblast growth factor 7 (FGF7) plays a role in cell growth and differentiation.
  • Accurate representation of protein localization is crucial for understanding cellular mechanisms.
  • Previous publication contained image duplication errors affecting FGF7 data.

Purpose:

  • To correct and clarify the representation of fibroblast growth factor 7 (FGF7) in specific cancer cell lines.
  • To ensure the integrity and accuracy of published scientific data.
  • To rectify image misidentification in the original article.

Summary:

  • The published article mistakenly duplicated images of cytoplasmic and nuclear FGF7 in MDA-MB-231 cells.
  • These duplicated images were incorrectly presented as total FGF7 in both SKBR-3 and MDA-MB-231 cells.
  • This correction addresses the misrepresentation of FGF7 protein in these cell lines.

Impact:

  • Ensures accurate data for future research on FGF7 in breast cancer.
  • Maintains scientific integrity and reproducibility.
  • Provides a reliable reference for cellular localization and expression of FGF7.

More Related Videos

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.8K
Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

7.1K

Related Concept Videos

Independent and Dependent Sources01:18

Independent and Dependent Sources

In electrical circuits, sources play a crucial role in providing power for the operation of the circuit. These sources can be broadly categorized into two types: independent and dependent.
Independent voltage or current sources supply a fixed amount of voltage or current, respectively, which is unaffected by other elements within the circuit. These are represented using specific symbols. Independent voltage sources are symbolized with polarities (+ and -), indicating the direction of the...
2.6K
Repressed Memory01:16

Repressed Memory

Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
511
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.1K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.0K
Introduction to Test of Independence01:21

Introduction to Test of Independence

In statistics, the term independence means that one can directly obtain the probability of any event involving both variables by multiplying their individual probabilities. Tests of independence are chi-square tests involving the use of a contingency table of observed (data) values.
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
3.0K
Hypothesis Test for Test of Independence01:16

Hypothesis Test for Test of Independence

The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
8.1K