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3D printed microfluidic viscometer based on the co-flowing stream.

Hyeonji Hong1, Jae Min Song2, Eunseop Yeom1

  • 1School of Mechanical Engineering, Pusan National University, Busan 46241, South Korea.

Biomicrofluidics
|March 15, 2019
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Summary
This summary is machine-generated.

A novel 3D printed microfluidic viscometer estimates viscosity using pressure and flow width, enabling easy measurement with small samples. This technology shows potential for portable, commercial viscometers, particularly for biological fluid analysis.

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Area of Science:

  • Fluid Dynamics
  • Materials Science
  • Biomedical Engineering

Background:

  • Accurate viscosity measurement is crucial across physical, chemical, and biological systems.
  • Conventional viscometers have limitations, necessitating innovative solutions for precise viscosity determination.

Purpose of the Study:

  • To propose and validate a novel three-dimensional (3D) printed microfluidic viscometer for simplified viscosity measurement.
  • To leverage pressure estimation between two fluids for viscosity analysis using minimal sample volumes.

Main Methods:

  • Fabrication of a microfluidic chip using 3D printing and amine-epoxy bonding.
  • Inducing an interfacial line by introducing sample and reference fluids into separate inlets.
  • Estimating sample viscosity (μ) by measuring the reference flow width relative to pressure ratios.

Main Results:

  • Experimental and simulation analysis confirmed the relationship between pressure, interfacial width, and mesh-like patterns in 3D printed viscometers.
  • Viscosity measurements of glycerol mixtures using the 3D printed viscometer closely matched conventional methods.
  • Demonstrated higher blood viscosity in diabetic patients compared to non-diabetic individuals across varying shear rates.

Conclusions:

  • The 3D printed microfluidic viscometer offers a viable method for accurate viscosity assessment with small sample volumes.
  • The technology shows significant potential for developing portable and commercially viable viscometers.
  • The device effectively differentiates viscosity profiles in biological samples, such as blood from diabetic and non-diabetic patients.