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Familial Hypercholesterolemia With Coexisting Renovascular Stenosis and Premature Coronary Artery Disease

Ojas H Mehta1, James D Cameron1, Sam Mirzaee1

  • 1Monash Cardiovascular Research Centre, MonashHEART, Monash Health, Monash University, Melbourne, Australia.

American Journal of Hypertension
|March 15, 2019
PubMed

Insights

Familial hypercholesterolemia (FH) is a genetic disorder causing high cholesterol. Early symptoms like heart attack in young adults signal the need for prompt FH diagnosis and management.

Area of Science:

  • Cardiology
  • Genetics
  • Metabolic Disorders

Background:

  • Familial hypercholesterolemia (FH) is a prevalent genetic lipid disorder.
  • It significantly increases the risk of premature atherosclerotic cardiovascular disease.
  • Early identification and management are crucial for preventing severe outcomes.

Observation:

  • A 31-year-old man presented with ST-elevated myocardial infarction.
  • He had a history of undertreated hypertension and hypercholesterolemia.
  • Investigations revealed renal and mesenteric arterial stenoses, suggesting secondary hypertension.

Findings:

  • The patient was diagnosed with Familial hypercholesterolemia (FH).
  • The case illustrates FH can manifest with early-onset cardiovascular events and arterial stenoses.
  • Hypertension and hypercholesterolemia in young individuals may indicate underlying FH.

Implications:

  • Highlights the importance of clinical vigilance for FH in young patients with early cardiovascular symptoms.
  • Emphasizes the need for comprehensive lipid and vascular assessments in such cases.
  • Underscores the link between FH, premature cardiovascular disease, and potential secondary hypertension.

Keywords:
atherosclerosisblood pressurecoronary artery diseasefamilial hypercholesterolemiahypertensionrenal artery stenosis

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