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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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[Dermatitis herpetiformis].

H A Juratli¹, A Görög², M Sárdy²

¹Klinik für Dermatologie und Allergologie, Universitätsklinikum Gießen und Marburg, Standort Marburg, Baldingerstr. 1, 35043, Marburg, Deutschland. juratlih@med.uni-marburg.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|March 15, 2019

Summary

Dermatitis herpetiformis (DH) is an autoimmune skin disease linked to gluten sensitivity. Diagnosis involves detecting IgA-TG3 immune complexes, and treatment requires a strict gluten-free diet.

Keywords:

Autoimmune diseases Coeliac disease Gluten sensitive enteropathy Immune complex Transglutaminase

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Area of Science:

Immunodermatology
Gastroenterology
Genetics

Background:

Dermatitis herpetiformis (DH) is a genetically determined, gluten-sensitive autoimmune bullous dermatosis.
It is associated with celiac disease and characterized by granular deposits of epidermal transglutaminase (TG3), IgA, and fibrinogen in the papillary dermis.
DH presents with itchy, erythematous papules, typically on the knees, elbows, and buttocks, though vesicles are infrequent.

Purpose of the Study:

To summarize the key aspects of Dermatitis herpetiformis (DH).
To highlight diagnostic criteria and therapeutic strategies for DH.

Main Methods:

Review of existing literature on Dermatitis herpetiformis.
Focus on diagnostic markers and treatment protocols.

Main Results:

The gold standard for DH diagnosis is the detection of dermal IgA-TG3 immune complexes.
DH affects a subset of individuals with gluten-sensitive enteropathy.
Characteristic skin lesions include excoriated papules with a specific distribution pattern.

Conclusions:

A strict, lifelong gluten-free diet is the primary treatment for DH.
Dapsone may be required for managing severe symptoms of DH.