Related Experiment Video
Updated: Jan 27, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
Published on: January 15, 2017
Acceptance of a propofol and remifentanil infusion dosing algorithm to optimize postoperative emergence and analgesia
Carl Tams1, Ken Johnson2, Christoph Seubert3
1Department of Anesthesiology, University of Utah, 30 N 1900 E, Salt Lake City, UT, 84132, USA. carl.tams@utah.edu.
Abstract:
We implemented a pharmacokinetic/pharmacodynamic (PK/PD) based optimization algorithm recommending intraoperative Remifentanil and Propofol infusion rates to minimize time to emergence and maximize the duration of analgesia in a clinical setting. This feasibility study tested the clinical acceptance of the optimization algorithm's recommendations during scoliosis surgical repair for 14 patients. Anesthesiologist accepted 359/394 (91%) of the recommendations given on the basis of the optimization algorithm. While following the optimization's recommendations the anesthesiologist decreased Propofol infusions from an average of 164-135 mcg/kg/min [p = 0.002] and increased Remifentanil infusions from an average of 0.22-0.30 mcg/kg/min [p = 0.004]. The anesthesiologists appeared to accept and follow the recommendations from a PK/PD based optimization algorithm.
Related Concept Videos
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Analgesia and Pain Management
Emerging Adulthood
Hypothesis: Accept or Fail to Reject?
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null...
Trial and Error and Algorithm
Dose Size and Dosing Frequency: Determination Methods

