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Published on: April 25, 2014
Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression
Lauren R Schaff1, Ashfaq Marghoob2, Marc K Rosenblum3
1Department of Neurology, Memorial Sloan Kettering Cancer Center, New York City, New York.
Abstract:
Neurocutaneous melanosis (NCM) is the condition of abnormal melanocyte deposition in the leptomeninges and brain parenchyma. Associated with congenital melanocytic nevi, NCM can result in neurologic deficits, hydrocephalus, and rarely, malignant transformation of cells. We present the case of a 16-year-old boy with NCM who developed malignant leptomeningeal melanoma following immunosuppression with a TNFα inhibitor. To our knowledge, this is the first reported case of a patient with known NCM undergoing malignant transformation after anti-TNF therapy for inflammatory bowel disease.
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