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Persistence of smoking induced non-small cell lung carcinogenesis by decreasing ERBB pathway-related microRNA

Lianmin Zhang1, Hailong Wang2, Changli Wang1

  • 1Department of Lung Cancer, Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Thoracic Cancer
|March 15, 2019
PubMed
Abstract

Insights

Smoking activates the ERBB pathway in non-small cell lung cancer (NSCLC) through specific microRNAs. These microRNAs, including hsa-mir-185-3p, promote NSCLC development by influencing the ERBB pathway.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Tobacco use is a primary cause of non-small cell lung cancer (NSCLC), accounting for 80-90% of cases.
  • The ERBB pathway is implicated in lung cancer development, but the specific mechanisms activated by smoking remain unclear.

Purpose of the Study:

  • To investigate the role of microRNAs in activating the ERBB pathway during smoking-induced lung cancer carcinogenesis.
  • To elucidate the molecular mechanisms linking smoking to ERBB pathway activation in NSCLC.

Main Methods:

  • Analysis of microRNA array data from the Gene Expression Omnibus and Kyoto Encyclopedia of Genes and Genomes.
  • Comparison of gene associations with smoking status in three patient groups: smokers, former smokers, and non-smokers with NSCLC.

Main Results:

  • Identified an interaction network among specific microRNAs (hsa-mir-185-3p, hsa-mir-4295, hsa-mir-4288, and hsa-mir-613).
  • This microRNA network promotes lung cancer development by affecting the ERBB pathway.

Conclusions:

  • The study provides evidence explaining the mechanism of lung cancer development in smokers.
  • Specific microRNAs play a crucial role in mediating the effects of smoking on the ERBB pathway in NSCLC.
Keywords:
EGFRlung cancermicroRNAsmoking

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