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Campylobacter jejuni capsule types in a Peruvian birth cohort and associations with diarrhoeal disease severity

Britney Neitenbach1, Frédéric Poly1, Janelle Kuroiwa1

  • 1Enteric Diseases Department,Naval Medical Research Center,Silver Spring, Maryland,USA.

Epidemiology and Infection
|March 15, 2019
PubMed

Insights

This study investigated Campylobacter jejuni capsule types and their link to diarrhoeal disease symptoms in Peruvian children. No significant association was found between common capsule types and symptomatic versus asymptomatic infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Campylobacter jejuni is a primary global cause of bacterial diarrhea.
  • Understanding virulence factors like capsule types is crucial for disease control.

Purpose of the Study:

  • To investigate the association between Campylobacter jejuni capsule types and clinical manifestations of diarrhea.
  • To analyze C. jejuni isolates from a Peruvian birth cohort for capsule type diversity and clinical correlation.

Main Methods:

  • Analysis of 318 C. jejuni isolates from children followed from birth to 2 years.
  • Utilized Pearson's chi-squared and Kruskal-Wallis tests to assess associations.
  • Identified 22 distinct C. jejuni capsule types, with five common types identified.

Main Results:

  • The five most prevalent capsule types (HS4 complex, HS5/31 complex, HS15, HS2, HS10) accounted for 49.1% of isolates.
  • No statistically significant difference in prevalence was observed between symptomatic and asymptomatic infections for any capsule type (p > 0.05).
  • The majority of isolates (82.7%) were predicted to have heptose-containing capsules, with common presence of methyl phosphoramidate, heptose, or deoxyheptose.

Conclusions:

  • Capsule type diversity in C. jejuni is high, even within a specific geographic cohort.
  • Specific C. jejuni capsule types, including common ones, do not appear to be significantly associated with the presence or absence of diarrheal symptoms in young children.
  • Further research may explore other C. jejuni factors influencing disease severity.

Keywords:
Campylobacter jejunicapsule typesmultiplex PCRpaediatric enteric diseasevaccine development

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