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Hospitalisations with infections related to antimicrobial-resistant bacteria from the French nationwide hospital

M Opatowski1, P Tuppin2, K Cosker3

  • 1Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Inserm, UVSQ, Institut Pasteur, Université Paris-Saclay,Paris,France.

Epidemiology and Infection
|March 15, 2019
PubMed

Insights

Antimicrobial resistance (AMR) infections in France caused over 139,000 hospitalizations in 2016. This highlights the significant burden of drug-resistant bacteria and the need for better public health strategies.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Public Health Policy

Background:

  • The widespread use of antibiotics has accelerated the rise of antimicrobial resistance (AMR), complicating infection treatment.
  • Comprehensive data on the overall AMR burden is scarce, hindering effective health policy development.
  • Estimating the national impact of AMR is crucial for public health planning.

Purpose of the Study:

  • To quantify the annual incidence of hospitalised patients with AMR infections in France.
  • To provide data-driven insights for informing national health policies on AMR.
  • To assess the prevalence of specific resistant bacterial strains.

Main Methods:

  • Utilized the National Hospital Discharge database (PMSI) for incident hospitalisations in 2016.
  • Analyzed acute infections linked to specific microorganisms.
  • Extrapolated bacterial species and resistance data by age, gender, and infection site for national estimates.

Main Results:

  • Resistant bacteria caused an estimated 139,105 infections, with a 12.3% overall resistance rate.
  • Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae and methicillin-resistant Staphylococcus aureus (MRSA) were the most prevalent resistant bacteria.
  • ESBL-producing Enterobacteriaceae accounted for 49,692 infections, and MRSA for 19,493 infections.

Conclusions:

  • AMR infections represent a substantial public health challenge in France, necessitating targeted interventions.
  • The study provides comprehensive national estimates despite inherent assumptions, underscoring the value of PMSI data.
  • Further research and policy development are needed to combat the growing threat of antimicrobial resistance.

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