Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CAR T-cell expansion after idecabtagene vicleucel is a predictor of outcomes in multiple myeloma.

HemaSphere·2026

Same author

Five trials reshaping multiple myeloma.

Med (New York, N.Y.)·2026

Same author

Development of a Fully Non-Viral 1XX-enhanced BCMA CAR-T Cell Therapy for Multiple Myeloma.

bioRxiv : the preprint server for biology·2026

Same author

Bispecific T-cell engagers in autoimmune diseases: mechanisms of action, clinical evidence challenges, and therapeutic perspectives.

Autoimmunity reviews·2026

Same author

[Bispecific T-cell engagers for the treatment of autoimmune diseases: Current status and therapeutic perspectives].

La Revue de medecine interne·2026

Same author

Patient-Centered Education Through A Massive Open Online Course (MOOC) for Patients With Multiple Myeloma and Caregivers: Descriptive Study of Knowledge Gains by French Association of Patients With Multiple Myeloma (AF3M) and French-Speaking Myeloma Intergroup (IFM).

JMIR formative research·2026

Same journal

[Prolonged fever].

La Revue du praticien·2026

Same journal

[Lower gastrointestinal bleeding].

La Revue du praticien·2026

Same journal

[Management of antiplatelet agents and oral anticoagulants in cases of gastrointestinal bleeding].

La Revue du praticien·2026

Same journal

[A history of child abuse intervention in the West].

La Revue du praticien·2026

Same journal

[Agranulocytose médicamenteuse].

La Revue du praticien·2026

Same journal

[Patient education in heart failure].

La Revue du praticien·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 27, 2026

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells

Published on: September 18, 2019

[Cryoglobulinemia for use].

Stéphanie Harel¹, Alexis Talbot¹

¹Service d'immunohématologie, hôpital Saint-Louis, AP-HP, Paris, France.

La Revue Du Praticien

|March 15, 2019

Summary

This summary is machine-generated.

Cryoglobulinemia involves cold-precipitating immunoglobulins, with Type I linked to B cell disorders and mixed types often to hepatitis C virus. Treatment strategies differ based on cryoglobulin type and symptom severity.

Keywords:

cryoglobulinemia for use

More Related Videos

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning

Published on: March 21, 2025

Separation and Identification of Conventional Microplastics from Farmland Soils

Separation and Identification of Conventional Microplastics from Farmland Soils

Published on: March 21, 2025

Related Experiment Videos

Last Updated: Jan 27, 2026

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells

Three-dimensional Angiogenesis Assay System using Co-culture Spheroids Formed by Endothelial Colony Forming Cells and Mesenchymal Stem Cells

Published on: September 18, 2019

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning

JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning

Published on: March 21, 2025

Separation and Identification of Conventional Microplastics from Farmland Soils

Separation and Identification of Conventional Microplastics from Farmland Soils

Published on: March 21, 2025

Area of Science:

Immunology
Hematology
Virology

Background:

Cryoglobulinemia is characterized by cold-precipitating immunoglobulins in circulation.
Two main subgroups exist: Type I and mixed cryoglobulins (Types II and III).
These subgroups have distinct physiopathology and treatment approaches.

Purpose of the Study:

To differentiate between cryoglobulinemia Type I and mixed cryoglobulins.
To outline the underlying causes and clinical manifestations of each type.
To discuss current therapeutic strategies based on cryoglobulin type and disease severity.

Main Methods:

Classification of cryoglobulins into Type I and mixed types.
Identification of associated conditions, such as monoclonal lymphoid B hemopathy and hepatitis C virus.
Clinical assessment of organ involvement (skin, peripheral nerves, renal glomerulus) and symptom severity.

Main Results:

Type I cryoglobulinemia is associated with monoclonal lymphoid B hemopathy.
Mixed cryoglobulinemia (Types II and III) is frequently linked to antigenic stimulation, most commonly hepatitis C virus.
Symptom intensity varies, with skin, peripheral nervous system, and renal glomerulus being most affected in symptomatic patients.

Conclusions:

Cryoglobulin typing is crucial for determining appropriate treatment.
Treatment for Type I cryoglobulinemia focuses on the underlying B cell clone.
Treatment for mixed cryoglobulinemia often involves immunosuppression and addressing the causative agent, if identified.