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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
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[Hepatitis B virus infection: control or cure?]

Marc Bourlière1, Valérie Oules1, Xavier Adhoute1

  • 1Service d'hépatogastroentérologie, hôpital Saint-Joseph, 26, bd de Louvain, 13008 Marseille, France.

La Revue Du Praticien
|March 15, 2019
PubMed

Insights

Hepatitis B virus (HBV) infection affects millions globally. Current treatments focus on controlling viral replication, but research aims for a cure by combining antiviral and immune therapies to achieve sustained HBsAg loss.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis B virus (HBV) infection is a significant global health concern with evolving epidemiology.
  • Chronic HBV infection affects approximately 254 million people worldwide, with host immune response crucial to pathogenesis.
  • Screening and vaccination are key public health strategies for managing HBV.

Purpose of the Study:

  • To review the current landscape of Hepatitis B virus infection control and explore pathways toward a potential cure.
  • To discuss the role of host immunity, screening, vaccination, and current treatment modalities.
  • To highlight future research directions for achieving a functional cure for HBV.

Main Methods:

  • Review of current literature on Hepatitis B virus infection epidemiology, pathogenesis, and treatment.
  • Analysis of existing therapeutic strategies, including nucleos(t)ide analogues and pegylated interferon.
  • Examination of research trends focusing on combination therapies and immune modulation.

Main Results:

  • Current treatments aim for long-term viral suppression and biochemical response, with functional cure (HBsAg loss) as an optimal goal.
  • Hepatitis B screening is recommended for individuals with risk factors or elevated ALT.
  • Vaccination strategies are crucial for prevention in newborns and at-risk populations.

Conclusions:

  • Achieving a cure for Hepatitis B virus infection requires a shift from viral suppression to immune restoration and complete viral clearance.
  • Future research focuses on combination therapies targeting multiple stages of the HBV lifecycle and enhancing host immune responses.
  • Developing treatments that lead to durable HBsAg loss and anti-HBs seroconversion remains the ultimate therapeutic objective.

Keywords:
hepatitis B

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