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Epidemiological features and risk factors for mortality in Pseudomonas aeruginosa bacteremia in children

María T Rosanova1, María S Mussini1, Ana P Arias2

  • 1Servicio de Control Epidemiológico e Infectología. Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires.

Archivos Argentinos De Pediatria
|March 15, 2019
PubMed

Insights

This study identified key risk factors for mortality in patients with bacteremia, including septic shock and intensive care unit admission. Multidrug resistance and specific infection sources also significantly increased mortality risk.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Critical Care Medicine

Background:

  • Bacteremia poses a significant threat, necessitating a comprehensive understanding of its characteristics and mortality predictors.
  • Identifying risk factors is crucial for timely intervention and improved patient outcomes in bacteremic patients.

Purpose of the Study:

  • To elucidate the epidemiological, clinical, microbiological, and evolutionary features of bacteremia.
  • To determine the independent risk factors associated with mortality in a cohort of bacteremic patients.

Main Methods:

  • A retrospective cohort study involving 100 patients diagnosed with bacteremia.
  • Data collection included patient demographics, clinical presentation, infection source, microbiological data, and outcomes.

Main Results:

  • Septic shock (42%) and intensive care unit (ICU) admission (56%) were common. Primary or secondary non-catheter-related bacteremia, mucocutaneous/pulmonary infection sources, and multidrug resistance (38%) were prevalent.
  • Mortality rate was 31%. Significant risk factors for mortality included septic shock, ICU admission, specific bacteremia types, infection source, and antimicrobial resistance (multidrug and carbapenem resistance).

Conclusions:

  • Septic shock, ICU admission, specific bacteremia origins, infection sites, and antimicrobial resistance are critical determinants of mortality in bacteremic patients.
  • These findings underscore the importance of early recognition and management of these risk factors to reduce mortality.

Keywords:
BacteremiaMortalityPediatricsPseudomonas aeruginosa

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