Related Experiment Video

Updated: Jan 27, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

11.3K

C188-9, a small-molecule STAT3 inhibitor, exerts an antitumor effect on head and neck squamous cell carcinoma

Jian-Xin Di1, Hong-Yan Zhang2

  • 1Department of Otorhinolaryngology.

Anti-Cancer Drugs
|March 15, 2019
PubMed

Insights

C188-9, a STAT3 inhibitor, shows antitumor effects against human head and neck squamous cell carcinoma (HNSCC) by inhibiting growth, migration, and invasion. This STAT3 suppression offers a promising therapeutic strategy for HNSCC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Signal transducer and activator of transcription 3 (STAT3) pathway dysregulation is implicated in human head and neck squamous cell carcinoma (HNSCC) progression.
  • STAT3 is a validated therapeutic target for various cancers, including HNSCC.

Purpose of the Study:

  • To investigate the antitumor potential of C188-9, a novel small-molecule STAT3 inhibitor, against HNSCC.
  • To elucidate the molecular mechanisms underlying C188-9's effects on HNSCC cells.

Main Methods:

  • In vitro assessment of C188-9's impact on HNSCC cell proliferation, cell cycle, apoptosis, migration, and invasion.
  • Evaluation of C188-9's effect on HNSCC chemosensitivity.
  • Analysis of STAT3 phosphorylation at Tyr705 following C188-9 treatment.

Main Results:

  • C188-9 significantly inhibited HNSCC cell growth, induced G0/G1 cell cycle arrest, and promoted apoptosis.
  • C188-9 exposure reduced HNSCC cell migration and invasion capacities.
  • C188-9 enhanced the chemosensitivity of HNSCC cells and inactivated STAT3 by decreasing Tyr705 phosphorylation.

Conclusions:

  • C188-9 demonstrates potent antitumor activity against HNSCC in vitro.
  • Suppression of the STAT3 pathway by C188-9 represents a promising therapeutic avenue for HNSCC management.

More Related Videos

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

8.9K
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

10.2K

Related Concept Videos

Arteries of the Head and Neck01:26

Arteries of the Head and Neck

The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
3.2K
Veins of Head and Neck01:19

Veins of Head and Neck

The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
5.5K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K
Muscles of the Anterior Neck01:26

Muscles of the Anterior Neck

The anterior neck muscles are the group of muscles covering the front part of the neck. These muscles are classified into three subgroups. The first one is the superficial muscles, the most visible muscles in the front of the neck. It includes the platysma and sternocleidomastoid. The second group is the suprahyoid muscles, located above the hyoid bone. This group comprises the digastric, mylohyoid, geniohyoid, and stylohyoid. Lastly, the infrahyoid muscles are found below the hyoid bone and...
4.7K
Muscles that Move the Head01:19

Muscles that Move the Head

The muscles that move the head are a dynamic and complex group of structures that work together to facilitate a wide range of head movements, including rotation, flexion, extension, and lateral bending.
The bilateral sternocleidomastoid, or SCM, and the suprahyoid and infrahyoid muscles are significant head flexors. The SCM muscles originate at the sternum and clavicle and attach to the mastoid process of the temporal bone. The SCM contracts bilaterally to bend the head forward, whereas...
5.8K
Molecules and Compounds02:38

Molecules and Compounds

Atoms and Molecules
68.5K