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Related Experiment Video

Updated: Jan 27, 2026

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients
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Neurosurgical contribution within a complex NF1 supraregional service.

H Raffalli-Ebezant1, K J George1, E Burkitt-Wright2

  • 1Department of Neurosurgery, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre, Salford, Greater Manchester, UK.

Clinical Neurology and Neurosurgery
|March 15, 2019
PubMed
Summary

This study reviewed neurosurgical activity in neurofibromatosis type I (NF1) patients over 8 years. A specialized multidisciplinary center managed 1505 cases, including 43 surgeries, improving NF1 surgical condition management.

Keywords:
Complex NF1Neurofibromatosis

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Area of Science:

  • Neurosurgery
  • Genetics
  • Oncology

Background:

  • Neurofibromatosis type I (NF1) is a genetic disorder with significant neurosurgical implications.
  • Management of NF1 patients requires a multidisciplinary approach due to complex pathologies.

Purpose of the Study:

  • To review and present neurosurgical activity at a specialized, nationally commissioned NF1 center.
  • To evaluate the outcomes and management strategies for neurosurgical conditions in NF1 patients.

Main Methods:

  • Retrospective review of all NF1 Neurosurgical Multidisciplinary Team (MDT) meetings, clinics, and surgical procedures.
  • Data collected over an 8-year period (2009 onwards).

Main Results:

  • 1505 NF1 cases discussed at multidisciplinary meetings.
  • 171 complex NF1 neurosurgical clinic appointments.
  • 43 cranial and spinal operations performed on NF1 patients.

Conclusions:

  • A supraregional multidisciplinary team enhances understanding and management of NF1 surgical conditions.
  • Holistic patient care is achieved through direct care, specialist advice, and local unit liaison.