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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Plaque Assay for Murine Norovirus
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Published on: August 22, 2012

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Autophagy and Noroviruses.

Kevin Furlong1, Seungmin Hwang2,3,4,5

  • 1Committee on Microbiology, The University of Chicago, Chicago, IL 60637, USA. furlongk@uchicago.edu.

Viruses
|March 16, 2019
PubMed
Summary

Autophagy, a cellular degradation process, has complex interactions with viruses. This review explores how autophagy proteins affect norovirus, highlighting key questions for future research.

Keywords:
LC3 conjugationautophagyinterferon-inducible GTPasesnoroviruspositive-sense RNA virusreplication compartment

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Area of Science:

  • Cell Biology
  • Virology
  • Molecular Biology

Background:

  • Autophagy is a fundamental cellular mechanism for degrading cytoplasmic components.
  • Viruses interact with autophagy, influencing their replication and survival.
  • The precise role of autophagy in norovirus infection remains incompletely understood.

Purpose of the Study:

  • To review the interactions between autophagy, autophagy-related proteins, and norovirus.
  • To identify and discuss unresolved questions regarding these interactions.

Main Methods:

  • Literature review of studies on autophagy and norovirus.
  • Analysis of known proviral and antiviral roles of autophagy in viral infections.
  • Synthesis of current knowledge on norovirus-autophagy interplay.

Main Results:

  • Autophagy can play diverse roles in viral life cycles, including proviral functions.
  • Norovirus interactions with autophagy are complex and not fully elucidated.
  • Specific autophagy proteins and their functions in norovirus replication require further investigation.

Conclusions:

  • Understanding the autophagy-norovirus relationship is crucial for comprehending norovirus pathogenesis.
  • Further research is needed to clarify the specific mechanisms and outcomes of autophagy modulation by norovirus.
  • Identifying therapeutic targets within the autophagy pathway could offer new strategies against norovirus infections.