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Updated: Jan 27, 2026

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Antidiabetic Properties of Naringenin: A Citrus Fruit Polyphenol
Danja J Den Hartogh1,2, Evangelia Tsiani3,4
1Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada. dd11qv@brocku.ca.
Abstract:
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance and hyperglycemia and is associated with personal health and global economic burdens. Current strategies/approaches of insulin resistance and T2DM prevention and treatment are lacking in efficacy resulting in the need for new preventative and targeted therapies. In recent years, epidemiological studies have suggested that diets rich in vegetables and fruits are associated with health benefits including protection against insulin resistance and T2DM. Naringenin, a citrus flavanone, has been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, immunomodulatory and antidiabetic properties. The current review summarizes the existing in vitro and in vivo animal studies examining the anti-diabetic effects of naringenin.
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