Related Experiment Video

Updated: Jan 27, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

2.2K

The MicroRNA miR-155 Is Essential in Fibrosis

Mousa G Eissa1, Carol M Artlett2

  • 1Department of Microbiology & Immunology, Drexel University College of Medicine, Drexel University, 2900 Queen Lane, Philadelphia, PA 19129, USA. mosa1034@gmail.com.

Non-Coding RNA
|March 16, 2019
PubMed

Insights

MicroRNAs (miRNAs), specifically miR-155, are key drivers of fibrosis by increasing collagen synthesis. Targeting miR-155 in pathological cells offers a potential antifibrotic strategy.

Area of Science:

  • Molecular Biology
  • Immunology
  • Cell Biology

Background:

  • MicroRNAs (miRNAs) play crucial roles in gene expression regulation.
  • Fibrotic disorders are characterized by excessive collagen deposition.
  • miR-155 is frequently upregulated in fibrotic conditions.

Purpose of the Study:

  • To review the role of miR-155 in fibrosis.
  • To elucidate the mechanisms of miR-155-mediated collagen synthesis.
  • To explore miR-155 as an antifibrotic therapeutic target.

Main Methods:

  • Literature review of studies on miR-155 and fibrosis.
  • Analysis of signaling pathways involving miR-155, TGF-β1, macrophages, and fibroblasts.
  • Discussion of immune system activation by miR-155.

Main Results:

  • miR-155 upregulation is consistently observed in fibrotic disorders.
  • miR-155 mediates TGF-β1 signaling, leading to increased collagen synthesis.
  • Cross-talk between macrophages and fibroblasts is orchestrated by miR-155 to promote collagen production.

Conclusions:

  • miR-155 plays an integral role in the pathogenesis of fibrotic disorders.
  • Targeting miR-155 in pathological cells is a promising antifibrotic strategy.
  • Further research into miR-155 depletion could lead to effective antifibrotic therapies.
Keywords:
TGF-β1fibroblastsfibrosisinflammasomemiR-155

More Related Videos

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells09:58

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

Published on: May 2, 2017

8.0K
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

6.0K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.0K
Compounds Essential to Human Function01:25

Compounds Essential to Human Function

The human body is composed of cells that are fundamentally made up of several different molecules. These molecules are essential to carry out all physiological processes in the body and are broadly classified into organic and inorganic based on their chemical structures.
Inorganic Compounds Essential to Human Functioning
Inorganic compounds essential to human functioning include water, salts, acids, and bases. These compounds are inorganic, i.e., they do not have a carbon-hydrogen bond. Water...
10.1K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.3K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
864
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
516