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Formation of Dispersible Taohong Siwu Tablets
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Co-processed excipients for direct compression of tablets.

Aleš Franc, David Vetchý, Pavlína Vodáčková

    Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti
    |March 16, 2019
    PubMed
    Summary

    Co-processed excipients offer solutions for direct compression tablet manufacturing challenges. These specialized blends improve content uniformity, disintegration, and hardness, optimizing tablet production.

    Keywords:
    co-processed excipients, direct compression, blends, tablets, physical characteristics

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    Area of Science:

    • Pharmaceutical Technology
    • Materials Science

    Background:

    • Tablets are a prevalent dosage form due to their accessibility, ease of administration, stability, and cost-effectiveness.
    • Direct compression is an efficient tablet manufacturing method but faces challenges like content uniformity, mass variation, and mechanical property control.

    Purpose of the Study:

    • To review excipients used in co-processed excipients.
    • To explore various manufacturing technologies for co-processed excipients.
    • To identify commercially available co-processed excipients suitable for direct compression.

    Main Methods:

    • Literature review of scientific databases and commercial product information.
    • Analysis of co-processed excipient compositions and manufacturing techniques.
    • Compilation of data on commercially available products for direct compression.

    Main Results:

    • Co-processed excipients are engineered blends of common pharmaceutical excipients (fillers, binders, disintegrants, lubricants).
    • Key manufacturing technologies include spray-drying, fluid bed granulation, wet granulation, melt granulation, dry granulation, and co-crystallisation.
    • Several commercial co-processed excipients are available, specifically designed to enhance direct compression.

    Conclusions:

    • Co-processed excipients effectively address direct compression limitations.
    • The selection of appropriate co-processed excipients and manufacturing technology is crucial for successful direct compression tablet formulation.
    • Advancements in co-processing offer improved solutions for pharmaceutical tablet manufacturing.