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Hepatitis A infection related haemophagocytic syndrome: a case report and systematic review

Bipadabhanjan Mallick1, Philip Daniel1, Usha Dutta2

  • 11 Senior Resident, Department of Gastroenterology, PGIMER, Chandigarh, India.

Tropical Doctor
|March 16, 2019
PubMed

Haemophagocytic lymphohistiocytosis (HLH) is a clinical syndrome of excessive inflammation and tissue destruction owing to abnormal immune activation. We report an unusual case of haemophagocytosis associated with hepatitis A virus (HAV) infection in a 21-year-old man. This was further complicated by haemolysis secondary to G-6-PD deficiency and fungal sepsis. Our patient was treated successfully with intravenous immunoglobulin (IVIg) and supportive care. A systematic review of all reported cases of HAV associated haemophagocytosis is presented.

Keywords:
Hepatitis Ahaemophagocytosisintravenous immunoglobulin

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