Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Learning effect of repeated hypercapneic ventilatory response testing.

K R Cooper, B A Phillips

    The American Journal of the Medical Sciences
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The AsTex: clinimetric properties of a new tool for evaluating hand sensation following stroke.

    Clinical rehabilitation·2009
    Same author

    Serological evidence for infection with Campylobacter jejuni/coli in patients with multifocal motor neuropathy.

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2008
    Same author

    The development of an aquatic bivalve model: evaluating the toxic effects on gametogenesis following 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) exposure in the eastern oyster (Crassostrea virginica).

    Aquatic toxicology (Amsterdam, Netherlands)·2006
    Same author

    Gait and balance impairment in early multiple sclerosis in the absence of clinical disability.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2006
    Same author

    Hazard evaluation of diisononyl phthalate and diisodecyl phthalate in a Japanese medaka multigenerational assay.

    Ecotoxicology and environmental safety·2005
    Same author

    Early onset chromosome 14-linked distal myopathy (Laing).

    Neuromuscular disorders : NMD·2002
    Same journal

    Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

    The American journal of the medical sciences·2026
    Same journal

    In Memoriam: Maurice A. Mufson, MD, MACP.

    The American journal of the medical sciences·2026
    Same journal

    Outcomes of Acute Myeloid Leukemia Patients Admitted to the Intensive Care Unit within 100 days of Allogeneic Hematopoietic Stem Cell Transplantation.

    The American journal of the medical sciences·2026
    Same journal

    Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

    The American journal of the medical sciences·2026
    Same journal

    Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

    The American journal of the medical sciences·2026
    Same journal

    The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

    The American journal of the medical sciences·2026
    See all related articles

    Repeated hypercapneic ventilatory response (HCVR) testing in healthy individuals revealed a learning effect, with the slope of HCVR increasing significantly by day 3. This response was primarily driven by subjects with higher initial HCVR values.

    Area of Science:

    • Physiology
    • Respiratory Medicine
    • Neuroscience

    Background:

    • Hypercapneic ventilatory response (HCVR) is a critical measure of respiratory control.
    • Understanding factors influencing HCVR variability is essential for accurate clinical assessment.
    • Repeated testing protocols may introduce learning effects impacting physiological measurements.

    Purpose of the Study:

    • To investigate the impact of repeated daily testing on hypercapneic ventilatory response (HCVR) in healthy subjects.
    • To identify potential learning effects associated with the rebreathing technique for HCVR assessment.
    • To determine if different subject subgroups exhibit distinct responses to repeated HCVR testing.

    Main Methods:

    • HCVR was measured daily for four consecutive days in 22 healthy subjects.

    Related Experiment Videos

  • The rebreathing technique was employed to induce progressive hypercapnia.
  • Key parameters measured included the slope (S) of HCVR and delta P0.1/delta PCO2.

    • Main Results:

    • The slope (S) of HCVR significantly increased by Day 3 (14% greater than Day 1, p < 0.05).
    • A subgroup of "increasers" (n=12) demonstrated a significant increase in S over the testing period.
    • "Increasers" had significantly higher baseline S values compared to "decreasers" (p < 0.001).
    • Delta P0.1/delta PCO2 showed no significant change, indicating differential sensitivity of measures.

    Conclusions:

    • Repeated daily HCVR testing can induce a learning effect in some healthy individuals.
    • Subjects with higher initial HCVR values are more likely to exhibit an increasing response with repeated testing.
    • While both S and delta P0.1/delta PCO2 measure ventilatory response, they are not interchangeable in normal subjects.