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The concept of stress concentration is crucial for understanding how materials respond under bending stresses, particularly when there are irregularities or discontinuities in the material's geometry. Normally, stress in a symmetric member subjected to pure bending is assumed to be uniformly distributed across the entire cross-section. However, this assumption does not hold when there are variations in the cross-sectional geometry or the presence of notches and holes.
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A fluvoxamine-related fatality: Case report with postmortem concentrations.

Jenna Otter1, Iain M McIntyre2, Jacquelyn Morhaime3

  • 1University of California San Diego, USA.

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|March 16, 2019
PubMed
Summary
This summary is machine-generated.

Fluvoxamine, a common antidepressant, can be fatal in overdose. A case study revealed acute fluvoxamine toxicity as the cause of death in an elderly man with high postmortem drug levels.

Keywords:
FluvoxamineOverdosePostmortem concentrationSSRI

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Area of Science:

  • Pharmacology
  • Toxicology
  • Forensic Medicine

Background:

  • Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) with a generally accepted safety profile in overdose.
  • However, known adverse effects at high concentrations include cardiac conduction abnormalities, QTc prolongation, hypotension, obtundation, and seizures.

Observation:

  • A deceased male in his 60s was discovered in his residence.
  • Postmortem toxicology revealed significant fluvoxamine concentrations: 4.9 mg/L in peripheral blood and 440 mg/kg in liver tissue.

Findings:

  • The cause of death was definitively attributed to acute fluvoxamine toxicity.
  • This case highlights the potential lethality of fluvoxamine overdose, challenging previous safety assumptions.

Implications:

  • Clinicians should be aware of the potential for severe toxicity and fatality with fluvoxamine overdose.
  • Forensic toxicologists and medical examiners must consider acute fluvoxamine toxicity in overdose investigations, especially with elevated postmortem levels.