Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Migration00:53

Migration

8.9K
Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
8.9K
Cell Migration01:19

Cell Migration

6.5K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.5K
Cell Migration01:09

Cell Migration

18.7K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.7K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.3K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

4.6K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.6K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

3.3K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D multi-omics tumour atlases: from technology to biology and clinical translation.

Nature reviews. Cancer·2026
Same author

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction.

bioRxiv : the preprint server for biology·2026
Same author

Deep Learning Enabled 3D Multi-Omic Analysis Reveals Molecular Signatures of Heterogeneous Response to Chemotherapy in Pancreatic Cancer.

bioRxiv : the preprint server for biology·2026
Same author

Accelerated discovery of cell migration regulators using label-free deep learning-based automated tracking.

Science advances·2026
Same author

iCLAP: an innovative method for integrable co-detection of low-abundance antigens with high-plex immunostaining.

Nature communications·2026
Same author

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Jan 27, 2026

De Novo Generation of Somatic Stem Cells by YAP/TAZ
13:05

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

9.6K

Enabling migration by moderation: YAP/TAZ are essential for persistent migration.

Praful R Nair1, Denis Wirtz2,3,4,5

  • 1Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD.

The Journal of Cell Biology
|March 16, 2019
PubMed
Summary
This summary is machine-generated.

Yes Associated protein (YAP) and Transcriptional coactivator with PDZ-binding motif (TAZ) proteins limit cytoskeletal tension, which is crucial for sustained cell migration. This finding impacts understanding of embryonic development and cancer metastasis.

More Related Videos

Nuclear Migration in the Drosophila Oocyte
04:17

Nuclear Migration in the Drosophila Oocyte

Published on: May 13, 2021

4.5K
In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

141.2K

Related Experiment Videos

Last Updated: Jan 27, 2026

De Novo Generation of Somatic Stem Cells by YAP/TAZ
13:05

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

9.6K
Nuclear Migration in the Drosophila Oocyte
04:17

Nuclear Migration in the Drosophila Oocyte

Published on: May 13, 2021

4.5K
In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

141.2K

Area of Science:

  • Cell Biology
  • Biophysics
  • Developmental Biology

Background:

  • Persistent cell migration is vital for numerous physiological processes.
  • The regulatory mechanisms governing sustained cell migration are not fully understood.

Purpose of the Study:

  • To investigate the role of YAP/TAZ proteins in regulating cell migration.
  • To elucidate the mechanisms by which cytoskeletal tension influences persistent cell movement.

Main Methods:

  • The study utilized advanced microscopy and genetic manipulation techniques.
  • Researchers analyzed the impact of YAP/TAZ activity on cytoskeletal dynamics and cell motility.

Main Results:

  • YAP/TAZ proteins were found to limit cytoskeletal tension.
  • Reduced cytoskeletal tension mediated by YAP/TAZ is essential for persistent, but not the initiation of, cell migration.

Conclusions:

  • YAP/TAZ signaling is a key regulator of cytoskeletal tension during cell migration.
  • These findings offer insights into developmental processes and the metastatic spread of cancer.