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Depiction of Oral Tumor-Induced Trigeminal Afferent Responses Using Single-Fiber Electrophysiology

Max Grayson1, Ashley Furr1, Shivani Ruparel2

  • 1Department of Endodontics, University of Texas Health at San Antonio, San Antonio, TX, USA.

Scientific Reports
|March 16, 2019
PubMed

Insights

Oral squamous cell carcinoma (OSCC) tumors sensitize trigeminal nerve endings, altering sensory fiber responses and contributing to oral cancer pain. This study reveals mechanisms of pain in tongue cancer.

Area of Science:

  • Neuroscience
  • Oncology
  • Pain Research

Background:

  • Oral tumors cause pain and altered sensations through poorly understood mechanisms.
  • Investigating trigeminal afferent neuron responses is crucial for understanding oral cancer pain.

Purpose of the Study:

  • To investigate how oral squamous cell carcinoma (OSCC) of the tongue affects the response properties of peripheral sensory fibers.
  • To elucidate the mechanisms by which oral tumors regulate sensory nerve activity.

Main Methods:

  • Developed an ex vivo method for single neuron recordings from the lingual nerve of isolated tongue tissue in a murine OSCC model.
  • Utilized single fiber electrophysiology to analyze the firing properties of lingual afferent neurons.

Main Results:

  • Tongue tumors significantly increased spontaneous firing of lingual fibers.
  • Mechanical hypersensitivity and reduced von Frey thresholds were observed in C- and A-slow-high-threshold mechanoreceptor (HTMR) fibers.
  • The proportion of mechanically-insensitive fibers decreased in tumor-bearing preparations.

Conclusions:

  • Human OSCC tumors sensitize peripheral trigeminal nerve terminals.
  • This sensitization contributes to the development of oral cancer pain.
  • Provides a model system for studying the mechanisms of oral cancer pain.

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