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The association analysis between HLA-A*26 and Behçet's disease
Jutaro Nakamura1,2, Akira Meguro3, Genji Ishii4
1Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan. nakamura.jutaro@hmw.gr.jp.
Scientific Reports
|March 16, 2019
Summary
The HLA-A*26 gene is a significant risk factor for Behçet's disease (BD) onset, particularly in Northeast Asia. This genetic association is independent of the well-known HLA-B*51 risk factor.
Area of Science:
- Immunogenetics
- Human Genetics
- Rheumatology
Background:
- Behçet's disease (BD) is a rare multisystem inflammatory disorder.
- HLA-B*51 is the strongest known genetic risk factor for BD.
- Previous research suggested HLA-A*26 may also contribute to BD risk independently.
Purpose of the Study:
- To re-evaluate the association between HLA-A*26 and BD in the Japanese population.
- To conduct a meta-analysis of published data on HLA-A*26 and BD risk.
- To estimate the odds ratio (OR) for HLA-A*26 in BD onset.
Main Methods:
- Genotyping of 611 Japanese BD patients and 2,955 healthy controls.
- Comprehensive literature search and meta-analysis of existing studies.
- Subgroup analysis by geographical regions (Northeast Asia, Middle East, Europe).
Main Results:
- HLA-A*26 was found more frequently in BD patients (OR=2.12).
- The association was stronger in HLA-B*51-negative BD patients (OR=3.10).
- Meta-analysis confirmed HLA-A*26 as a risk factor (OR=1.80), especially in HLA-B*51-negative individuals (OR=4.02), and specifically in Northeast Asia.
Conclusions:
- HLA-A*26 is an independent genetic risk factor for Behçet's disease.
- The association of HLA-A*26 with BD is geographically specific, primarily observed in Northeast Asia.
- These findings refine our understanding of the genetic architecture of Behçet's disease.
