Intratumor heterogeneity inferred from targeted deep sequencing as a prognostic indicator
Bo Young Oh1, Hyun-Tae Shin2, Jae Won Yun2
1Department of Colorectal Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Scientific Reports
|March 16, 2019
Summary
Tumor heterogeneity, measured by a novel index from deep sequencing, correlates with cancer progression and poor prognosis. This index shows promise as a prognostic indicator for cancer patients.
Area of Science:
- Oncology
- Genomics
- Cancer Research
Background:
- Tumor genetic heterogeneity can lead to metastatic and drug-resistant cancer, impacting clinical outcomes.
- Targeted deep sequencing is a key diagnostic tool for identifying actionable mutations in cancer.
Purpose of the Study:
- To evaluate the clinical utility of estimating tumor heterogeneity using targeted panel sequencing data.
- To investigate the prognostic impact of a tumor heterogeneity (TH) index on clinical outcomes across various cancer types.
Main Methods:
- Analysis of mutational profiles from targeted deep sequencing data.
- Inclusion of 1,352 patients across 8 cancer types.
- Development and application of a tumor heterogeneity (TH) index.
Main Results:
- The TH index increased with higher pathological stage in several cancer types, suggesting clonal expansion during tumor progression.
- In colorectal cancer, TH index values significantly correlated with clinical prognosis.
- Integration of the TH index with genomic and clinical features enhanced risk prediction power.
Conclusions:
- Deep sequencing to determine the TH index is a promising prognostic indicator for cancer patients.
- The TH index reflects tumor progression and has prognostic value.
- Combining TH index with other features improves clinical outcome prediction.
Related Concept Videos
02:39Indicators
60.4K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
60.4K
01:15Theory of Attribution I: Correspondent Inference Theory
507
Correspondent inference theory, proposed by Jones and Davis in 1965, seeks to explain how individuals infer stable personality traits from observed behaviors. It suggests that people attribute actions to underlying dispositions rather than external circumstances, particularly when the behavior appears intentional and socially significant.Voluntary Behavior and Dispositional AttributionAccording to this theory, individuals are more likely to attribute behavior to personal traits when it appears...
507
01:29Mechanical Ventilation I: Indication and Settings
2.8K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.8K
01:19Respiratory Assessment: Purpose and Indications
1.8K
Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
1.8K
01:16Statistical Inference Techniques in Hypothesis Testing: Parametric Versus Nonparametric Data
482
Statistical inference techniques, paramount in hypothesis testing, differentiate into two broad categories: parametric and nonparametric statistics.
Parametric statistics, as the name suggests, assumes that data follow a specific distribution, often a normal distribution. This assumption enables robust hypothesis testing and estimation. Parametric methods, like the Student's t-test or Goodness-of-fit test, are frequently employed in biostatistics due to their robustness. For instance,...
Parametric statistics, as the name suggests, assumes that data follow a specific distribution, often a normal distribution. This assumption enables robust hypothesis testing and estimation. Parametric methods, like the Student's t-test or Goodness-of-fit test, are frequently employed in biostatistics due to their robustness. For instance,...
482
02:02Cis-regulatory Sequences
11.7K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.7K