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Updated: Jan 27, 2026

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
Published on: January 3, 2011
Dual-axis confocal microscopy for point-of-care pathology
Linpeng Wei1, Chengbo Yin1, Jonathan T C Liu1
1Department of Mechanical Engineering, University of Washington, Seattle, WA 98195 USA, JTCL is also with the Department of Pathology at the University of Washington.
Abstract:
Dual-axis confocal (DAC) microscopy is an optical imaging modality that utilizes simple low-numerical aperture (NA) lenses to achieve effective optical sectioning and superior image contrast in biological tissues. The unique architecture of DAC microscopy also provides some advantages for miniaturization, facilitating the development of endoscopic and handheld DAC systems for in vivo imaging. This article reviews the principles of DAC microscopy, including its differences from conventional confocal microscopy, and surveys several variations of DAC microscopy that have been developed and investigated as non-invasive real-time alternatives to conventional biopsy and histopathology.
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