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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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The Current Landscape of Treatment in Non-Metastatic Castration-Resistant Prostate Cancer

Joelle El-Amm1, Jeanny B Aragon-Ching2

  • 1Hematology and Oncology, Lebanese American University, Beirut, Lebanon.

Clinical Medicine Insights. Oncology
|March 16, 2019
PubMed

Insights

Novel anti-androgens like apalutamide and enzalutamide offer new hope for non-metastatic castration-resistant prostate cancer (nmCRPC). This review covers pivotal trials and discusses the benefits and challenges of these advanced prostate cancer treatments.

Area of Science:

  • Oncology
  • Urology
  • Medical Science

Background:

  • Non-metastatic castration-resistant prostate cancer (nmCRPC) presents a significant unmet need in advanced prostate cancer management.
  • The disease is characterized by heterogeneity and variable progression to overt metastases.
  • Historically, treatment options for nmCRPC were limited.

Purpose of the Study:

  • To review pivotal clinical trials leading to the FDA approval of apalutamide and enzalutamide for nmCRPC.
  • To explore early data on the efficacy of darolutamide in this patient population.
  • To discuss the promises and challenges associated with novel anti-androgen therapies in nmCRPC.

Main Methods:

  • Review of pivotal clinical trials for apalutamide and enzalutamide in nmCRPC.
  • Analysis of early data for darolutamide in nmCRPC.
  • Discussion of treatment benefits and challenges based on trial outcomes.

Main Results:

  • Apalutamide and enzalutamide have demonstrated significant metastasis-free survival benefits in nmCRPC.
  • These novel anti-androgens represent a major advancement in treating advanced prostate cancer.
  • Early data suggests darolutamide also shows promise in the nmCRPC setting.

Conclusions:

  • Recent FDA approvals of apalutamide and enzalutamide have transformed nmCRPC treatment paradigms.
  • These novel anti-androgens offer improved outcomes, particularly in delaying metastasis.
  • Careful consideration of their benefits and challenges is crucial for optimal patient management.
Keywords:
ODM-201apalutamidedarolutamideenzalutamidemetastasis-free survivalnon-metastatic CRPC

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