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Related Experiment Videos

Complement Therapeutics in the Multi-Organ Donor: Do or Don't?

Judith E van Zanden1, Neeltina M Jager1, Mohamed R Daha2,3

  • 1Department of Surgery, University Medical Center Groningen, Groningen, Netherlands.

Frontiers in Immunology
|March 16, 2019
PubMed
Summary
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Complement activation in deceased organ donors compromises graft quality. Targeting this system offers a potential strategy to improve donor organ outcomes and transplant success rates.

Area of Science:

  • Transplantation immunology
  • Organ preservation
  • Complement system biology

Background:

  • Organ transplantation is a successful treatment for end-stage organ failure.
  • Immune system activation, particularly complement activation, limits long-term graft survival.
  • Complement activation occurs early, even within the donor, impacting organ quality.

Purpose of the Study:

  • To review current knowledge on complement activation in deceased organ donors.
  • To explore the role of complement in deceased donor pathophysiology.
  • To discuss complement therapeutics for improving donor organ quality.

Main Methods:

  • Literature review of complement activation in organ donation.
  • Analysis of studies on ischemia-reperfusion injury and rejection.
Keywords:
complement systemcomplement therapeuticsdeceased after brain deathdeceased after circulatory deathdonor managementorgan donor

Related Experiment Videos

  • Examination of complement therapeutics tested in donors.

    • Main Results:

    • Complement activation in deceased donors is linked to poorer organ quality.
    • Most donor organs come from brain-dead or circulatory death donors, where complement's role is underexposed.
    • Targeting the complement system shows therapeutic potential for donor organs.

    Conclusions:

    • Complement activation is a critical factor affecting deceased donor organ quality.
    • Therapeutic strategies targeting the complement system may enhance organ viability.
    • Further investigation is needed to determine clinical translation and organ-specific targets for complement therapeutics.