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Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp2)-H activation and C(sp3)-H
Liangliang Song1, Guilong Tian1, Johan Van der Eycken2
1Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001, Leuven, Belgium.
Abstract:
A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp2)-H activation and C(sp3)-H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance.
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