Oncogenic Hijacking of the PIN1 Signaling Network

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Alessandro Zannini1,2, Alessandra Rustighi1,2, Elena Campaner1

  • 1National Laboratory CIB, Trieste, Italy.

Frontiers in Oncology
|March 16, 2019
PubMed

Insights

PIN1 (Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) regulates cell signaling pathways through post-translational modifications. This review explores its role in normal physiology and cancer, highlighting therapeutic potential.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cellular signal transduction pathways are regulated by post-translational modifications (PTMs).
  • PIN1 (Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) mediates post-phosphorylation prolyl-isomerization, a unique PTM controlling signal transduction.
  • PIN1 activity is influenced by hormonal, nutrient, and oncogenic stimuli, suggesting conserved regulatory circuits.

Purpose of the Study:

  • To review the molecular mechanisms and cellular processes regulated by PIN1 in physiological conditions.
  • To discuss how cancer cells subvert PIN1-mediated pathways.
  • To address the current status and future directions of PIN1 as a biomarker and therapeutic target in cancer.

Main Methods:

  • Literature review of studies on PIN1 function in various model organisms and humans.
  • Analysis of molecular mechanisms underlying PIN1-mediated regulation of proliferation, metabolism, and stem cell fate.
  • Examination of PIN1's role in cancer development and progression.

Main Results:

  • PIN1 is crucial for controlling activation levels of multiple signaling pathways and biological outcomes.
  • PIN1 regulates fundamental cellular processes including proliferation, metabolism, and stem cell differentiation.
  • Dysregulation of PIN1 pathways is implicated in cancer pathogenesis.

Conclusions:

  • PIN1 plays a vital role in cellular signaling and physiological processes.
  • Targeting PIN1 offers a promising strategy for cancer therapy.
  • Further research is needed to fully elucidate PIN1's role and optimize its clinical application as a biomarker and therapeutic target.
Keywords:
cancer target therapyorganismal developmentpost-translational modificationprolyl-isomerase PIN1signal transductiontissue integritytumor development and progression

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