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Related Experiment Video

Updated: Jan 27, 2026

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
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Zinc and skin: an update.

Valerie Glutsch1, Henning Hamm1, Matthias Goebeler1

  • 1Department of Dermatology, Venereology and Allergology, University Medical Center, Würzburg, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|March 16, 2019
PubMed
Summary

Zinc deficiency, including acrodermatitis enteropathica, impacts skin health and development. Early diagnosis and oral zinc therapy are crucial for managing this essential trace element disorder.

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Genetics

Background:

  • Zinc (Zn) is vital for human tissue development, differentiation, and growth.
  • Zinc homeostasis relies on solute-linked carrier (SLC) families, with disruptions causing skin disorders.
  • Acrodermatitis enteropathica, an autosomal recessive disorder, stems from ZIP4 transporter gene mutations, leading to intestinal malabsorption.

Purpose of the Study:

  • To review the clinical manifestations, diagnosis, and management of zinc deficiency disorders.
  • To highlight the importance of recognizing acquired zinc deficiency, a rare but underdiagnosed condition.
  • To emphasize the role of dermatologists, pediatricians, and gastroenterologists in patient care.

Main Methods:

  • Clinical diagnosis based on characteristic periorificial and acral lesions.
  • Laboratory confirmation via plasma zinc level measurement.
  • Supplementary diagnosis using zinc-dependent enzymes like alkaline phosphatase.

Main Results:

  • Oral zinc replacement therapy often achieves rapid clinical remission.
  • Acquired zinc deficiency presents with variable clinical manifestations and diverse etiologies.
  • Early diagnosis and intervention are key for favorable outcomes.

Conclusions:

  • Zinc deficiency disorders require prompt recognition and management.
  • Multidisciplinary collaboration is essential for comprehensive patient care.
  • Understanding zinc metabolism is critical for treating related dermatological conditions.