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Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
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Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review

Leila Kafshdooz1,2, Houman Kahroba2,3, Tayebeh Kafshdooz3

  • 1a Womens Reproductive Health Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

Artificial Cells, Nanomedicine, and Biotechnology
|March 16, 2019
PubMed

Labour is considered to be one of the most painful procedures in human experience. The most effective technique for pain relief during labour is neuraxial labour analgesia which provides analgesia without maternal or fetal sedation. Genetic predisposition may be of importance for pain perception and women experience varying degrees of pain in labour. Genetic variations in opioid receptor (OPR) genes may influence the response to epidural opioid analgesia during labour. The single-nucleotide polymorphism, A118G of the mu opioid receptor gene (oprm1), has been associated with altered pain perception. Targeted drug delivery reduces toxic side effects. Liposomes, nano-particles, nanofibres hydrogel, have been suggested to deliver anaesthetic drugs.

Keywords:
Laboranalgesiagenenanocarriersopioid receptorpolymorphism

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