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Streptococcus pneumoniae: Invasion and Inflammation.
Allister J Loughran1, Carlos J Orihuela2, Elaine I Tuomanen1
1Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105.
Microbiology Spectrum
|March 16, 2019
Summary
Streptococcus pneumoniae causes major infections like pneumonia and meningitis. This review details how the bacterium colonizes, spreads, and causes inflammation and disease.
Area of Science:
- Microbiology
- Immunology
- Infectious Diseases
Background:
- Streptococcus pneumoniae is a primary cause of otitis media, community-acquired pneumonia, and bacterial meningitis.
- Its persistence as a commensal and evasion of the immune system contribute to its success.
Purpose of the Study:
- To review the molecular mechanisms of pneumococcal colonization and spread.
- To discuss inflammatory and cytotoxic mechanisms in pneumococcal infections.
Main Methods:
- Literature review of molecular mechanisms.
- Analysis of colonization, spread, inflammation, and cytotoxicity.
Main Results:
- Detailed review of molecular strategies for pneumococcal colonization and host-cell interaction.
- Discussion of virulence factors contributing to inflammation and tissue damage.
Conclusions:
- Understanding pneumococcal pathogenesis is crucial for developing effective treatments and vaccines.
- Molecular insights into colonization and immune evasion are key to combating pneumococcal diseases.
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