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A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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Crystal Field Theory
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Related Experiment Video

Updated: Jan 27, 2026

IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
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Iridium(iii) complex-based electrochemiluminescent probe for H2S.

Joonho Park1, Taemin Kim, Hoon Jun Kim

  • 1Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea. jihong@snu.ac.kr.

Dalton Transactions (Cambridge, England : 2003)
|March 16, 2019
PubMed
Summary
This summary is machine-generated.

A new iridium-based electrochemiluminescent (ECL) probe detects hydrogen sulfide (H2S) with high sensitivity. This probe enables rapid and selective H2S detection, crucial for understanding H2S-related diseases.

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Area of Science:

  • Analytical Chemistry
  • Biomedical Sensing
  • Inorganic Chemistry

Background:

  • Abnormal hydrogen sulfide (H2S) levels are linked to various diseases.
  • Simple, rapid, and sensitive H2S detection methods are in high demand for diagnostics.

Purpose of the Study:

  • To develop a novel electrochemiluminescent (ECL) probe for sensitive and selective H2S detection.
  • To investigate the sensing mechanism of the probe in response to H2S.

Main Methods:

  • Design and synthesis of a cyclometalated iridium(iii) complex as an ECL probe.
  • Utilizing o-(azidomethyl)benzoate ester functional groups for selective H2S reaction.
  • Employing 1H NMR spectroscopy and MALDI-TOF mass spectrometry to elucidate the sensing mechanism.

Main Results:

  • The probe exhibits a significant ECL "turn-off" response upon reaction with H2S.
  • Demonstrated high selectivity for H2S over common anions and biothiols.
  • The structural change upon H2S interaction was confirmed via spectroscopic analyses.

Conclusions:

  • The developed iridium(iii) complex serves as an effective ECL probe for H2S detection.
  • The probe's ECL quenching mechanism is attributed to unfavorable electron transfer after H2S-induced structural modification.
  • This method offers a promising tool for H2S monitoring in biological and chemical contexts.