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Updated: Jan 27, 2026

Area-based Image Analysis Algorithm for Quantification of Macrophage-fibroblast Cocultures
Published on: February 15, 2022
Beware greedy algorithms
Benno I Simmons1, Christoph Hoeppke1,2, William J Sutherland1
1Conservation Science Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Abstract:
To fairly compare the nestedness of ecological networks, a network's observed nestedness can be divided by its maximum nestedness. The authors show that a greedy algorithm does not find networks' maximum nestedness values. Simulated annealing achieved much better results, laying the foundation for future development of even more sophisticated algorithms.
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