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[Cognitive disorders in Behçet's disease].

P S Ovcharov1, T A Lisitsyna1, D Yu Veltishchev2

  • 1Nasonova Research Institute of Rheumatology, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|March 16, 2019
PubMed
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Cognitive disorders are common in Behçet

Area of Science:

  • Neuroscience
  • Rheumatology
  • Psychiatry

Background:

  • Behçet's Disease (BD) is a multisystemic inflammatory disorder.
  • Cognitive disorders (CD) and mental health issues are increasingly recognized in BD patients.
  • Understanding the prevalence and correlations of CD in BD is crucial for patient management.

Purpose of the Study:

  • To determine the prevalence of cognitive disorders (CD) in Behçet's Disease (BD) patients.
  • To investigate the clinical and pathogenetic correlations of CD in BD.

Main Methods:

  • 106 BD patients were assessed using psychiatric interviews and validated scales (MADRS, HAM-A).
  • Cognitive functions (memory, attention, logic) were evaluated using clinical/psychological methods.
  • Brain MRI was performed on a subset of patients to identify neurological changes.
Keywords:
Behçet’s diseasecognitive disordersmental disordersneurological disorders

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Main Results:

  • Cognitive disorders (mild to moderate) were diagnosed in 77.4% of BD patients.
  • Anxiety-depressive disorders were prevalent in 76.4% of BD patients, significantly higher in those with CD.
  • Patients with CD were older and showed a higher frequency of subcortical white matter lesions on MRI.

Conclusions:

  • Cognitive disorders are a characteristic feature in the majority of BD patients.
  • CD in BD are associated with older age, anxiety-depressive disorders, chronic stressors, and minor MRI-detected brain lesions.