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Related Experiment Video

Updated: Jan 27, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

Systemic Immunotherapy for Advanced Cutaneous Squamous Cell Carcinoma.

Dai Ogata¹, Tetsuya Tsuchida²

¹Department of Dermatology, Saitama Medical University, Morohongo 38, Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan. dai.ogata@gmail.com.

Current Treatment Options in Oncology

|March 16, 2019

Summary

Advanced cutaneous squamous cell carcinoma (cSCC) is challenging to treat. New anti-PD-1 antibody treatments offer a promising option for patients ineligible for surgery or radiation.

Keywords:

Chemotherapy Immunotherapy Metastasis Radiotherapy Squamous cell carcinoma of the skin Targeted therapy Unresectable

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Last Updated: Jan 27, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma

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Published on: April 12, 2024

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Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

Published on: March 17, 2020

Area of Science:

Oncology
Dermatology
Medical Research

Background:

Advanced cutaneous squamous cell carcinoma (cSCC) presents a significant treatment challenge with poor prognosis.
Metastatic cSCC has a low 10-year survival rate, especially with distant involvement.
Current treatments like platinum-based therapy have limitations due to toxicity, particularly in elderly patients.

Purpose of the Study:

To review the current landscape of systemic therapy for advanced cutaneous squamous cell carcinoma.
To highlight the limited evidence for systemic treatments due to a lack of prospective studies.
To introduce novel therapeutic approaches for advanced cSCC.

Main Methods:

Review of existing literature on systemic therapies for advanced cSCC.
Analysis of treatment outcomes and toxicity profiles.
Examination of recent FDA approvals for novel agents.

Main Results:

Traditional platinum-based therapies offer some efficacy but are often limited by toxicity.
Epidermal growth factor receptor (EGFR) inhibitors represent a less toxic alternative.
The anti-PD-1 antibody cemiplimab has been approved for advanced cSCC patients unsuitable for curative treatments.

Conclusions:

Systemic therapy for advanced cSCC remains an area with limited high-quality evidence.
Cemiplimab, an anti-PD-1 antibody, shows promise as a new treatment option for advanced cSCC.
Further research is needed to establish optimal systemic treatment strategies for advanced cSCC.