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Updated: Jan 27, 2026

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
12:04

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy

Published on: August 14, 2012

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Therapeutic sequences in patients with grade 1-2 neuroendocrine tumors (NET): an observational multicenter study from

Antongiulio Faggiano1, Silvana Di Maio2, Carmela Mocerino3

  • 1Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. antongiulio.faggiano@uniroma1.it.

Endocrine
|March 16, 2019
PubMed
Abstract

Insights

For grade 1-2 neuroendocrine tumors (NET), somatostatin analogs (SSA) followed by high-dose SSA or peptide receptor radionuclide therapy (PRRT) are well-tolerated treatment sequences. These approaches show comparable progression-free survival to everolimus or chemotherapy but with fewer side effects.

Area of Science:

  • Oncology
  • Endocrinology
  • Medical treatment efficacy

Background:

  • Guidelines suggest multiple treatments for grade 1-2 neuroendocrine tumors (G1-G2 NET).
  • A definitive therapeutic algorithm for G1-G2 NET remains elusive.
  • This study investigates established treatment sequences for G1-G2 NET.

Purpose of the Study:

  • To identify and compare the primary therapeutic sequences used for G1-G2 NET.
  • To evaluate treatment efficacy and safety profiles of different therapeutic sequences.

Main Methods:

  • A retrospective, observational, multicenter study was conducted in Italy.
  • Data from 131 patients with G1-G2 NET from the ELIOS database were analyzed.
  • Progression-free survival (PFS), side effects, and treatment discontinuation rates were compared across four main therapeutic sequences.

Main Results:

  • Four main sequences were identified: SSA to high-dose SSA (n=36), SSA to everolimus (n=31), SSA to chemotherapy (n=17), and SSA to PRRT (n=15).
  • Median PFS did not significantly differ between sequences (p=0.16).
  • Sequences involving everolimus or chemotherapy exhibited significantly higher rates of side effects and treatment discontinuation compared to high-dose SSA or PRRT (p=0.04 and p=0.03, respectively).

Conclusions:

  • Somatostatin analogs (SSA) followed by high-dose SSA, everolimus, chemotherapy, or PRRT are the main therapeutic sequences for G1-G2 NET.
  • While median PFS was similar across sequences, high-dose SSA and PRRT were better tolerated.
  • These findings suggest that high-dose SSA or PRRT may be preferable second-line treatments due to improved tolerability.
Keywords:
High-dose somatostatin analogsNeuroendocrine tumorsPRRTSequence of treatmentsSomatostatin analoguesTargeted therapy

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