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Updated: Jan 27, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Clinical decision support for high-cost imaging: A randomized clinical trial
Joseph Doyle1, Sarah Abraham2, Laura Feeney3
1Sloan School of Management, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
Clinical Decision Support (CDS) software can reduce inappropriate high-cost imaging orders by 6%. This study suggests CDS may improve the appropriateness of advanced imaging, aligning with upcoming Centers for Medicare and Medicaid Services (CMS) mandates.
Area of Science:
- Health economics
- Medical informatics
- Radiology
Background:
- High-cost imaging utilization raises concerns regarding patient safety and escalating healthcare expenditures.
- Potentially inappropriate imaging orders contribute significantly to these costs.
- The Centers for Medicare and Medicaid Services (CMS) is implementing a mandate for Clinical Decision Support (CDS) integration with high-cost imaging orders.
Purpose of the Study:
- To evaluate the impact of Clinical Decision Support (CDS) on healthcare provider ordering behaviors for high-cost imaging.
- To assess whether CDS influences the appropriateness of advanced imaging orders.
- To provide evidence on the effectiveness of CDS in response to the impending CMS mandate.
Main Methods:
- A randomized trial involving 3,511 healthcare providers at Aurora Health Care.
- Implementation of CDS software providing best practice alerts for targeted imaging orders.
- Analysis of changes in provider ordering patterns for high-cost, low-cost, and targeted imaging scans.
Main Results:
- CDS implementation led to a statistically significant 6% reduction in targeted (potentially inappropriate) imaging orders.
- No statistically significant changes were observed in the total number of high-cost or low-cost imaging scans ordered.
- The study indicates a modest improvement in the appropriateness of high-cost imaging orders attributable to CDS.
Conclusions:
- Clinical Decision Support (CDS) tools can effectively decrease the ordering of targeted, potentially inappropriate high-cost imaging.
- While overall high-cost scan volumes remained unchanged, CDS shows promise in enhancing imaging appropriateness.
- The findings support the anticipated positive impact of the CMS mandate on judicious use of advanced imaging services.
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