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Capture and Release of Viable Circulating Tumor Cells from Blood
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Multi-targeting magnetic hyaluronan capsules efficiently capturing circulating tumor cells.

Shaohua Ma1, Xiaoxi Zhou2, Qiang Chen2

  • 1National Engineering Research Center for Biomaterials, 29 Wangjiang Road, Chengdu 610064, PR China; Dynamiker Biotechnology (Tianjin) Co., Ltd., Sino-Singapore Tianjin Eco-City, Tianjin 300467, PR China; State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, PR China.

Journal of Colloid and Interface Science
|March 16, 2019
PubMed
Summary

This study introduces multi-targeting magnetic capsules (TMCs) for efficient capture of circulating tumor cells (CTCs). These novel capsules improve CTC isolation from blood samples, aiding cancer detection and monitoring.

Keywords:
CaptureCirculating tumor cellsMagnetic capsulesMulti-targeting

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Characterization of Tumor Cells Using a Medical Wire for Capturing Circulating Tumor Cells: A 3D Approach Based on Immunofluorescence and DNA FISH
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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Accurate detection and isolation of circulating tumor cells (CTCs) are crucial for cancer prognosis and treatment monitoring.
  • Existing immuno-magnetic strategies for CTC enrichment can be influenced by CTC origin and cell cycle.
  • There is a need for improved methods to capture rare CTCs from complex biological samples.

Purpose of the Study:

  • To develop and evaluate multi-targeting magnetic capsules (TMCs) for enhanced capture of rare circulating tumor cells (CTCs).
  • To combine natural immune recognition and tumor-specific ligand targeting for improved CTC isolation.
  • To assess the efficiency and utility of TMCs in both mimic samples and clinical blood samples.

Main Methods:

  • Construction of fluorescence-visible magnetic capsules (MCs) using fluorescently-labeled thiolated hyaluronan (RhB-HA-SH) and superparamagnetic Fe3O4 nanoparticles via ultra-sonication.
  • Functionalization of MCs with folic acid (FA) and anti-epithelial-cell-adhesion-molecule (anti-EpCAM) antibody to create TMCs.
  • Evaluation of TMCs' capture efficiency using MCF-7 cells in mimic biological samples and CTCs in cancer patient peripheral blood.

Main Results:

  • The developed TMCs demonstrated efficient capture of over 88% of rare MCF-7 cells in mimic samples within 15 minutes.
  • Isolated cells retained good proliferation and migration abilities, suitable for further CTC studies.
  • Successful capture and detection of few CTCs from 1.5 mL of cancer patient peripheral blood samples were achieved.

Conclusions:

  • Multi-targeting magnetic capsules (TMCs) offer a promising approach for the efficient capture and detection of rare circulating tumor cells (CTCs).
  • The simple and fast magnetic manipulation of TMCs makes them a viable tool for clinical applications in cancer diagnostics.
  • This technology facilitates further research into CTCs by enabling their isolation with preserved biological functions.