Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adhesion01:14

Adhesion

43.9K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
43.9K
Histone Modification02:32

Histone Modification

16.1K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.1K
Histone Modification02:32

Histone Modification

4.5K
4.5K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.4K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.4K
Behavior Modification01:21

Behavior Modification

630
Behavioral approaches have often been criticized for ignoring mental processes and focusing solely on observable behavior. However, these approaches provide an optimistic perspective for individuals seeking to change their behaviors. Rather than concentrating on intrinsic personality traits, behavioral approaches suggest that even longstanding habits can be modified by changing the reward contingencies that maintain them.
A real-world application of operant conditioning principles is applied...
630
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

3.3K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simultaneous determination of levonorgestrel and two endogenous sex hormones in human plasma based on LC-MS/MS.

Bioanalysis·2016
Same author

Management of full-length complete ureteral avulsion.

International braz j urol : official journal of the Brazilian Society of Urology·2016
Same author

Enhanced therapeutic efficacy and amelioration of cisplatin-induced nephrotoxicity by quercetin in 1,2-dimethyl hydrazine-induced colon cancer in rats.

Indian journal of pharmacology·2016
Same author

Linked Sensitivity Analysis, Calibration, and Uncertainty Analysis Using a System Dynamics Model for Stroke Comparative Effectiveness Research.

Medical decision making : an international journal of the Society for Medical Decision Making·2016
Same author

Trimester- and Assay-Specific Thyroid Reference Intervals for Pregnant Women in China.

International journal of endocrinology·2016
Same author

Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.

Bioorganic & medicinal chemistry letters·2016

Related Experiment Video

Updated: Jan 27, 2026

Assessment of Boron Doped Diamond Electrode Quality and Application to In Situ Modification of Local pH by Water Electrolysis
13:09

Assessment of Boron Doped Diamond Electrode Quality and Application to In Situ Modification of Local pH by Water Electrolysis

Published on: January 6, 2016

15.4K

Effect by Diamond Surface Modification on Biomolecular Adhesion.

Yuan Tian1, Karin Larsson2

  • 1Department of Chemistry-Ångström Laboratory, Uppsala University, BOX 538, 75121 Uppsala, Sweden. yuan.tian@kemi.uu.se.

Materials (Basel, Switzerland)
|March 17, 2019
PubMed
Summary
This summary is machine-generated.

Diamond surface termination significantly impacts biomolecule adhesion for implants. The (111) surface generally shows stronger binding, with Bone Morphogenetic Protein 2 (BMP2) adhering most strongly.

Keywords:
biomoleculesdiamondtheory

More Related Videos

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

11.4K
Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation
14:46

Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

Published on: January 20, 2018

8.2K

Related Experiment Videos

Last Updated: Jan 27, 2026

Assessment of Boron Doped Diamond Electrode Quality and Application to In Situ Modification of Local pH by Water Electrolysis
13:09

Assessment of Boron Doped Diamond Electrode Quality and Application to In Situ Modification of Local pH by Water Electrolysis

Published on: January 6, 2016

15.4K
Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

11.4K
Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation
14:46

Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

Published on: January 20, 2018

8.2K

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Biotechnology

Background:

  • Diamond exhibits excellent properties like biocompatibility and chemical inertness, making it suitable for medical implants.
  • Surface termination is critical for controlling diamond's interaction with biological molecules.
  • Understanding biomolecule adhesion is key for applications in vascularization and bone regeneration.

Purpose of the Study:

  • To investigate the influence of diamond surface termination and crystallographic plane on biomolecule adhesion.
  • To analyze the binding strength of key biomolecules relevant to tissue regeneration on different diamond surfaces.

Main Methods:

  • Theoretical calculations were performed to simulate the non-covalent binding of biomolecules to diamond surfaces.
  • The study considered two primary diamond surface planes: (100)-2x1 and (111).
  • Adhesion was assessed for biomolecules including Arginine-Glycine-Aspartic acid (RGD), Chitosan, Heparin, Bone Morphogenetic Protein 2 (BMP2), Angiopoietin 1 (AGP1), Fibronectin, and Vascular Endothelial Growth Factor (VEGF).

Main Results:

  • Biomolecule non-covalent binding strength generally correlates with molecular weight.
  • Three distinct binding groups were identified: BMP2 (strongest), smaller polypeptides (RGD, Chitosan, Heparin) (weakest), and VEGF, Fibronectin, AGP1 (intermediate).
  • The diamond (111) surface demonstrated superior biomolecule adhesion compared to the (100)-2x1 surface.

Conclusions:

  • Diamond surface properties, specifically termination and plane, critically affect biomolecule adhesion.
  • The (111) surface offers enhanced binding potential for therapeutic biomolecules.
  • These findings provide insights for designing diamond-based scaffolds for improved vascularization and bone regeneration.