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Capillary leak-syndrome triggered by Maripa virus in French Guiana: case report and implication for pathogenesis

Hatem Kallel1, Séverine Matheus2, Claire Mayence3

  • 1Service de Réanimation Polyvalente, Centre Hospitalier Andrée Rosemon de Cayenne, Avenue des Flamboyants, 6006 97306, Cayenne, BP, French Guiana. kallelhat@yahoo.fr.

BMC Infectious Diseases
|March 17, 2019
PubMed
Abstract

Insights

Maripa virus caused a severe Hantavirus Pulmonary Syndrome (HPS) in French Guiana. This HPS severity is due to the virus targeting microvascular endothelial cells, causing capillary leak syndrome.

Area of Science:

  • Infectious Diseases
  • Virology
  • Critical Care Medicine

Background:

  • Reports a severe case of Hantavirus Pulmonary Syndrome (HPS) caused by Maripa virus in French Guiana.
  • Aims to elucidate the mechanism behind the severe presentation of this human disease.

Observation:

  • A 47-year-old patient presented with fever, dyspnea, cough, and headache, rapidly progressing to respiratory, hemodynamic, and renal failure.
  • Intensive care unit admission revealed elevated hematocrit with low protein levels.
  • Hemodynamic monitoring indicated normal left ventricular function but high extravascular lung water and pulmonary vascular permeability, consistent with capillary leak syndrome (CLS).

Findings:

  • Maripa virus infection can lead to severe Hantavirus Pulmonary Syndrome.
  • The pathogenesis involves the virus's tropism for microvascular endothelial cells.
  • This tropism results in a systemic capillary leak syndrome.

Implications:

  • Understanding the mechanism of Maripa virus-induced HPS is crucial for clinical management.
  • Identifies capillary leak syndrome as a key factor in HPS severity.
  • Highlights the need for further research into hantavirus tropism and its clinical consequences.
Keywords:
Capillary leak-syndromeHantavirusMaripaPulmonary syndrome

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