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H3K27M-Positive Primary Spinal Glioblastoma Presenting with Hemorrhage-A Rare Clinical Entity
Alok Uppar1, Subhas K Konar1, Nandeesh B N2
1Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.
Background:
Primary spinal glioblastoma multiforme is a rare and aggressive spinal tumor with dismal outcomes CASE DESCRIPTION: We have presented an unusual case-the first, to the best of our knowledge, to be reported-with intratumoral hemorrhage and sudden-onset quadriplegia in a patients with primary spinal glioblastoma multiforme. The patient underwent emergency surgical decompression. The patient died after a prolonged intensive care unit stay.
Conclusion:
The tumor was positive for histone molecular alteration, H3K27M.
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