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Updated: Jan 27, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
The emerging role of sorting nexins in cardiovascular diseases
Jian Yang1,2, Van Anthony M Villar3, Selim Rozyyev3
1Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 410020, P.R. China jianyang@hospital.cqmu.edu.cn chunyuzeng01@163.com.
Abstract:
The sorting nexin (SNX) family consists of a diverse group of cytoplasmic- and membrane-associated phosphoinositide-binding proteins that play pivotal roles in the regulation of protein trafficking. This includes the entire endocytic pathway, such as endocytosis, endosomal sorting, and endosomal signaling. Dysfunctions of SNX pathway are involved in several forms of cardiovascular disease (CVD). Moreover, SNX gene variants are associated with CVDs. In this review, we discuss the current knowledge on SNX-mediated regulatory mechanisms and their roles in the pathogenesis and treatment of CVDs.
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