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ADS-J1 disaggregates semen-derived amyloid fibrils

Jinqing Li1, Zichao Yang1, Han Liu1

  • 1Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, Guangdong Province, China.

The Biochemical Journal
|March 17, 2019
PubMed
Summary

ADS-J1 effectively disassembles semen-derived amyloid fibrils (SEVI) and other amyloid structures. This compound shows potential as a dual-action microbicide and a therapeutic for amyloid diseases.

Keywords:
HIVSEVIamyloiddisaggregatemolecular dynamics

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